3 BOX IMPRYL FOOD SUPPLEMENT (3 x 30 TABLETS)
NEW
Impryl is the antioxidant support with methylfolate to restore oxy-redox balance, energy production and cell viability for the health of the embryo and of the pregnancy and for a controlled ageing
Feeding and activating the endogenous antioxidant defenses
Impryl is the benchmark of the antioxidants support. According to the new strategy, instead of using antioxidant substances, that act only on a limited number of sensitive pathways and that may generate negative counter effects, Impryl leverage on the physiologic antioxidant system to achieve a better oxy-redox balance within the control of the natural cellular homeostasis.
This approach is resulting in clinical improvements that appeared impossible by using traditional antioxidant molecules. In addition Impryl contains only substances normally present in the diet for a easy and safe use with no limits of duration.
Its formula contains all the substances required for the activation of antioxidant defenses in the absence of any substance with direct antioxidant activity. Moreover, it supplies the substances capable of compensating for the possible presence of the most common pathological variants of metabolic enzymes, in particular:
Folic acid in its methylated, active form (methylfolate) to compensate for a possible defect of the enzyme MTHFR (Methylene-Tetra-Hydro-Folate-Reductase)
Vitamin B12in its methylated, active form (methylcobalamine) to compensate for a possible defect of the enzyme MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase)
Betaine (trimethyl glycine) to compensate for a possible defect of the enzyme CHDH (choline-dehydrogenase)
Cysteine donor (cystine) to compensate for a possible defect of the enzyme CBS (cystathionine beta synthetase)
Thus, Impryl provides the maximum possible support to the antioxidant defenses and will be active in all subjects independently of their genetic substrate.
Impryl is completely free from direct antioxidants and works by inducing the endogenous cellular antioxidant defenses that, subject to the regulation of cellular homeostasis, will act as far as necessary and useful to the cell.
Mechanism of action:
Impryl is the first antioxidant dietary supplement based on a well defined mechanism of action: indirect antioxidant activity by means of the modulation of the enzyme CBS that regulates the synthesis of glutathione (GSH), the primary cellular antioxidant.
Impryl works by activating the primary biochemical cycle of our cells, the trans-methylations. This effect, besides globally improving the health of the cells, is mandatory to activate the physiologic antioxidant defenses, i.e the synthesis of GSH. The output of GSH and the antioxidant defenses are further supported by adding several specific substrates. The availability of methylfolate and methylcobalamine allow to compensate the most common defective variants of metabolic enzymes, namely MTHFR and MTRR.
Thus, the substances provided by Impryl allow the cells to activate the endogenous antioxidant defenses. The resulting antioxidant effect is comprehensive, i.e. affecting all the thousands metabolic reactions of concern, and associated to a beneficial influence on cell growth and differentiation. These effects occur within the control of the physiologic regulation of cellular activities and will never be excessive but will stop as soon the need will be satisfied, independently of the assumed amount.
Removing insulin resistance:
Insulin is a pancreatic hormone that stimulates the uptake of glucose into the cells so to make it available for the production of energy within the cellular mitochondria. A defect of insulin activity causes accumulation of glucose in the blood (hyperglycaemia). Insulin resistance is a condition characterized by low sensitivity of the insulin receptors. When insulin resistance affects the whole body, including muclular tissues, it is responsible for Diabetes Mellitus type 2, when affecting mainly the ovarian follicles in fertile women it sustains the development of the Polycystic Ovary Syndrome (PCOS).
It has been now discovered that insulin resistance is actually a defensive mechanism aimed at avoiding cellular damage from excess of endogenous reactive oxygen species (ROS). Indeed, when too much of glucose and other energy substrates are processed the endogenous production of ROS may increase too much if mitochondrial GSH is not enough to neutralise. To avoid final damage the mitochondria signal to the cell to block the insulin receptor to avoid further entrance of glucose and further ROS generation. Impryl induces more abundant GSH into the cells and their mitochondria thus improving their ability to neutralise the endogenous ROS. As a consequence glucose enters again into the cells and the insulin resistance is removed. This property of Impryl supplementation is the main reason for its positive effect on diabetes type 2 and on PCOS as well as in other conditions sustained by excess endogenous ROS such as neurodegenerations.
Substances contained in Impryl:
L-cystine, betaine, niacin, chelated zinc, riboflavin, vitamin B6, folic acid in methylated form (vitamin B6), vitamin B12 in methylated form (methylcobalamine).
